Transit Options

Consider walking or riding your bicycle rather than driving. Join a Bike/Pedestrian Committee: Lewisburg Borough Bike/Ped Subcommittee or East Buffalo Township Pedestrian and Bicycle Committee.
Consider carpooling. Invite a friend along.
Taxi or limousine service in Lewisburg area.

Mass transit options

Daily buses to NYC via Susquehanna Trailways. Check out their tours as well as other destinations.
Bucknell University runs occasional bus trips to NYC, Washington, DC and other locales that are open to the public. Bucknell bus info is at their Activities and Campus Events ACT website under UpComing BIG Events. Sign up early for all university bus trips to ensure a seat.
Susquehanna University runs occasional bus trips to NYC, Washington, DC and other locales that are open to the public. I am guessing the SU bus trips would be listed in their current Insider Newsletter. If anyone knows a better way to find out about their bus trips please email LAN LANmail@googlegroups.com. Some people like the central drop of point of Rockefellar Center and early NYC departure time of 8 pm. Sign up early for all university bus trips to ensure a seat.
The Greater Susquehanna Penn State Alumni Chapter also runs occasional bus trips. Membership is "open to ANYONE in the Central Pennsylvania area interested in supporting Penn State University. Our membership dues are $15.00 per family membership and run from August – July". Buses often leave from the Ames parking lot on SR 15 in Lewisburg. Sign up early for all university bus trips to ensure a seat.

France offers bicycles throughout Paris for anyone to use via a credit card. First 30 minutes is free. Other cities world-wide are considering implementing this service.
The Community Solution Ride-Share would use cell phones and vehicles modified with a Global Positioning System to coordinate drivers, riders, and a routing system.
Gristmill suggests a CyberTran of Ultra-light rails for urban and suburban areas.